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Open access to 10 high-end Core Facilities and assisted expertise

Facilities are provided by CEITEC and BIOCEV in Brno and Vestec near Prague

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Events

19–21 Mar 2026

The XXII Discussions in Structural Molecular Biology and the 9th User Meeting of CIISB

The Czech national conference with focus on structural biology The XXII Discussions in Structural Molecular Biology and the 9th User meeting of CIISB will be held in Nové Hrady, South Bohemia, on 19-21 March 2026. Conference details and the registration page will appear early in January 2026 on the web page of the Czech Society for Structural Biology.

Events calendar

News

28 Nov

Biophysicist for the core facility of Centre of Molecular Structure

We are seeking a molecular biophysicist to join the Centre of Molecular Structure (CMS), part of the Czech Infrastructure for Integrative Structural Biology. The Centre also provides research services within Instruct-ERIC, the European infrastructure for structural biology. It brings together several core facilities, providing a comprehensive approach to studying the three-dimensional structure, function, and biophysical properties of biological molecules.

5 Nov

New CIISB Service for Interpretation of Structural Flexibility and Dynamics Using Molecular-Dynamics Simulations

We are introducing Computer simulations for structural data interpretation as a new offering among CIISB’s service portfolio. The new service will run in pilot mode during 2026-2027 to evaluate the user interest and optimize the service offering in accordance with the user community needs.

30 Oct

HeliX+ Biosensor instrument (BRUKER) was purchased to the Biophysical Techniques Facility of CMS

HeliX⁺ Biosensor instrument from BRUKER was purchased to the Biophysical Techniques Facility of Centre of Molecular Structure. It enables the study of molecular interactions, including kinetics, affinity and avidity and reveals conformational changes induced by analyte binding or buffer conditions with switchSENSE analysis. This DNA-lever based technology is particularly advantageous for molecules interacting with modifying oligonucleotides.

17 Oct

CF Protein Production - Our tissue culture room is ready for new projects

In 2025, we successfully launched full-scale recombinant protein expression in both insect and mammalian systems. Our services include production in insect cells using BacPAK™ and FlexiBAC baculovirus systems, small-scale transfection with western blot verification, baculovirus amplification, and large-scale protein production in Sf9 or High Five™ cells.

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Research highlights

Pavel Plevka Lab of Structural Virology

High-resolution cryo-electron microscopy reconstruction of Staphylococcus aureusbacteriophage P68 from the family Podoviridae. P68 has potential to be used for phage therapy.
Richard Štefl Lab of Structural Biology

NMR structure shows how the CTD-interacting domain of Rtt103p recognizes threonine-4 phosphorylated CTD of RNA polymerase II (RNAPII). This study suggests that the CTD code of RNAP II is degenerated as the same interaction pocket of Rtt103p can read two different phosphorylation patterns of the CTD using the same structural mechanism.

Jasnovidova, O., Krejcikova, M., Kubicek, K. & Stefl, R. Structural insight into recognition of phosphorylated threonine-4 of RNA polymerase II C-terminal domain by Rtt103p. Embo Reports 18, 906-913, doi:10.15252/embr.201643723 (2017).

Core Facilities

CEITEC Core Facilities

BIOCEV Core Facilities

Equipment and services