Scanning probe microscopies for imaging of biological samples - tissue slices, cells, single biomolecules as nucleic acids and proteins. Studies of affinity interactions at the molecular level.

Key Equipment

    • Scanning probe microscope - Ntegra Vita / Solaris (NTMDT)
    • Atomic force microscope NanoWizzard3 (JPK)
    • ForceRobot 300 (JPK)
    • Automated system SolverNEXT (NTMDT)
    • Ink-jet based deposition system S3 (Scienion)


    • Studies of biomolecules and other bio-objects at the molecular level using scanning probe techniques, i.e. atomic force microscopy (AFM) and related techniques (STM, SNOM, electrochemical variants), including combinations with optical microscopy (inverted, fluorescence, confocal)
    • Production and bioconjugation of nanoparticles
    • Advanced methods - nanolithograpy, nanomechanical manipulations, ink-jet based deposition


    • Preparation of samples for AFM
    • Atomic force microscopic (AFM) imaging in contact and non-contact modes in dry and wet conditions, using bare and functionalised scanning tips for bioforce and biointeraction studies
    • Combination of AFM with inverted optical microscopy, fluorescence and confocal microscopy, electrochemistry, near-field optical microscopy (SNOM)
    • Nanomanipulations, nanolitography, nanopatterning and nanodeposition of biomolecules

Core Facility contact

Jan Přibyl -

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More information about Nanobiotechnology and related services you can find in document Equipement and services of CIISB .

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