Diffraction Techniques

Diffraction techniques core facility provides services for characterization of protein structure using single crystal X-ray diffraction and small-angle X ray scattering for analysis of liquid samples. The quality of high-intense X-ray beams is enabled by using of MetalJet sources (Excillum). The service provided includes data processing and reporting ready for publication.

Key Equipment

  • D8 Venture diffractometer (Bruker)
    • Single crystal diffractometer with a high-flux liquid Gallium X-ray source MetalJet D2, Photon II detector and Kappa goniometer
    • High resolution studies in cryogenic conditions
    • ISX stage (Bruker) - motorized stage for in-situ X-ray diffraction experiments, enabling screening of diffraction properties in crystallization plates
    • HC-Lab - controlled humidity of crystal environment for crystal dehydratation and room temperature experiments
  • SAXSpoint 2.0 (Anton Paar)
    • Measurement of SAXS or WAXS
    • The instrument is equipped with MetalJet C2+ X-ray source (Excillum), Eiger 1M detector (Dectris)
    • Automatic sample delivery
    • In-situ UV-Vis spectrometer (Agilent)
    • Liquid chromatography system (Akta Go, GE Healthcare) for SEC-SAXS experiments


  • Screening for X-ray diffraction of macromolecules
  • In-house data collection and processing
  • In-situ evaluation of X-ray diffraction of sensitive crystallization targets
  • Experimental phasing experiments – evaluation for MIR, SAD and MAD approaches
  • SAXS data measurement and evaluation, including SEC-SAXS
  • In-situ UV-Vis monitoring
  • Synchrotron-based data collection and processing, structure solution


  • Assisted use of all experimental equipment, hosting prolonged experiments (in-house experimental phasing), “service” data collection at synchrotron sources of radiation in individual cases, capacity dedicated to methods development, long-term documented cryo-storage

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