"Hydrodynamic and thermodynamic analysis of biological macromolecules and their interactions: multi-method approaches and global data analyses" practical course
Course will provide theoretical, practical and data analysis training in modern biophysical methods used to monitor and quantify molecular interactions.
Instruct-ERIC workshop on Computational Approaches in Integration of Structural Biology Techniques
On October 8 – 10, the Institute of Biotechnology of the Czech Academy of Sciences organised an Instruct – ERIC workshop on Computational Approaches in Integration of Structural Biology Techniques.
The 2019 Nobel Prize in Chemistry
Is awarded to John Goodenough, M. Stanley Whittingham and Akira Yoshino “for the development of lithium-ion batteries”.
The Nobel Prize in Physiology or Medicine 2019
is awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.”
The Nobel Prize in Physics 2019
is awarded ”for contributions to our understanding of the evolution of the universe and Earth’s place in the cosmos”, with one half to James Peebles “for theoretical discoveries in physical cosmology” and the other half jointly to Michel Mayor and Didier Queloz “for the discovery of an exoplanet orbiting a solar-type star.”
Renowned structural chemist Professor Sir Chris Dobson dies
Professor Sir Chris Dobson, a renowned structural chemist, has died.
New webpage on ciisb.org
A new page “Who is Who in Czech Structural Biology” has been added to the web site of CIISB
Save the date
Save the date – March 19-21, 2020
The XVII. Discussions in Structural Biology and 4th Users Meeting of Czech Infrastructure for Integrative Structural Biology (CIISB) jointly organized by Czech Society for Structural Biology and CIISB will take place in Nové Hrady, March 19 - March 21, 2020.
Reader's Corner Archive
Role of integrative structural biology in understanding transcriptional initiation
Role of integrative structural biology in understanding transcriptional initiation is discussed by Philip Robinson et. al. in a review, which presents a general background to integrative structural biology, describes of how it should be practically implemented, and shows how it has furthered our understanding of the biology of large transcriptional assemblies.
Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies
In this publication Sriram Subramaniam et. al. report on structural studies of G protein–coupled receptors, spliceosomes, and fibrillar specimens and illustrate the progress made by advanced cryo-EM methods.
The evolution of solution state NMR pulse sequences through the ‘eyes’ of triple-resonance spectroscopy
Lewis Kay in The evolution of solution state NMR pulse sequences through the ‘eyes’ of triple-resonance spectroscopy highlights how pulse sequence ‘engineering’ has evolved during past decades with the focus on liquid state NMR applications.
Principles for Integrative Structural Biology Studies
Guru of integrative structural biology computation Andrej Sali and Michale P. Rout summarize in the recent Cell Primer Principles for Integrative Structural Biology Studies.
Visualization of biological macromolecules at near-atomic resolution: cryo-electron microscopy comes of age
The topical review by Alok K. Mitra recapitulates developments and transformational advances of cryo-EM technology.
The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryo-EM
Samar Hasnain et. al. describe the steadily-expanding methodologies for atomic resolution studies in The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryo-EM. Of note is the following statistics: Despite the wealth of structures in the Protein Data Bank, a closer examination reveals that 89% of the structures, i.e. 126 994, are of proteins or complexes with a molecular weight of less than 160 kDa. Furthermore, only 4% of the deposited structures have a molecular weight in excess of 300 kDa.