What’s ahead of us - A growing number of research agencies is assigning money randomly
Using lottery as a fairer and more open system in awarding grants? Read an interesting Nature’s article about a new trend.
Update of roadmap of Large Research Infrastructures of the Czech Republic
A new update of Roadmap of Large Research Infrastructures of the Czech Republic is now available.
Save the date - NMR Valtice
35th Central European NMR Meeting will take place in Valtice in April 19-22 2020.
ARIA Workshop and User Group meeting
Instruct-ERIC is hosting an ARIA workshop and User Group meeting on 25th February in Amsterdam.
CIISB UP project approved for financing during 2020-2022
The project CIISB UP submitted to the OP VVV Call 02-18-046 Research Infrastructures II has been positively evaluated and will receive funding to reinvest into the existing equipment and to purchase new instrumentation in the amount 22 mil. EUR.
Magnetic Resonance - An Interactive Open Access Publication of the Groupement AMPERE
The AMPERE Society has decided to launch a new publication called “Magnetic Resonance, An Interactive Open Access Publication of the Groupement AMPERE” for articles on Nuclear and Electron Magnetic Resonance and Imaging.
Advanced SAXSanalysis trainingWe would like to invite you to an Advanced SAXSanalysis training.The training is designed to help you with processing data collected with small angle X-ray scattering (SAXS) instrument in the Centre of Molecular Structure in the Institute of Biotechnology of the Czech Academy of Sciences in BIOCEV. The tutorials will be by application specialist Anton Paar (instrument manufacturer).
Astbury Launch Event
On 25 November 2019, the Astbury Biostructure Laboratory will be formally launched as an Instruct-ERIC site. To welcome the Astbury Biostructure Laboratory to Instruct-UK, Instruct-ERIC and the Astbury Centre are hosting a launch event at Nexus at the University of Leeds.
Reader's Corner Archive
Compressive Force Spectroscopy: From Living Cells to Single Proteins
One of the most successful applications of atomic force microscopy (AFM) in biology involves monitoring the effect of force on single biological molecules, often referred to as force spectroscopy. A less recognized variation of this method, the application of compressive force, allows studies from large samples (living cells) to smaller, multi-molecular complexes (viruses) down to single protein molecules. These studies have enabled the detailed characterization of individual cell states, subtle differences between seemingly identical viral structures, as well as the quantification of rate constants of functionally important, structural transitions in single proteins. Here, Daniel Mark Czajkowsky et. al. briefly review some of the recent achievements and highlight exciting areas of its future development.
RNA Dynamics by NMR Spectroscopy
To reveal dynamic processes and higher energy structures, new NMR methods have been developed to elucidate dynamics in RNA with atomic resolution. In this review, Katja Petzold et. al. provide an introduction to dynamics novices and an overview of methods that access most dynamic timescales, from picoseconds to hours.
How Good Can Single-Particle Cryo-EM Become? What Remains Before It Approaches Its Physical Limits?
Impressive though the achievements of single-particle cryo–electron microscopy are today, a substantial gap still remains between what is currently accomplished and what is theoretically possible. As is reviewed by Robert M. Glaeser, twofold or more improvements are possible as regards (a) the detective quantum efficiency of cameras at high resolution, (b) converting phase modulations to intensity modulations in the image, and (c) recovering the full amount of high-resolution signal in the presence of beam-induced motion of the specimen. In addition, potential for improvement is reviewed for other topics such as optimal choice of electron energy, use of aberration correctors, and quantum metrology. With the help of such improvements, it does not seem to be too much to imagine that determining the structural basis for every aspect of catalytic control, signaling, and regulation, in any type of cell of interest, could easily be accelerated fivefold or more.
Potential of cryo-EM for high-resolution structural analysis of gap junction channels
The review by Oshima et. al. in Current Opinions in Structural Biology outlines structural biology of gap junction channels utilizing crystallography and single-particle cryo-EM to shed light on the functional mechanisms of cell-cell communication that are essential for multicellular organisms.
Molecular dynamics simulations of macromolecular crystals
The paper of David Case and David Cerutti in WIREs Computational Molecular Science evaluates past fusions of simulations and crystallography and looks ahead to the ways that simulations of crystal structures will enhance structural biology in the future.
Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein–RNA Complexes
In this publication Fred Allain et.al. reviews recent advances in hybrid structural approaches with a focus on combining MS analysis of cross-linked protein–RNA complexes and NMR spectroscopy.
Quo Vadis Biomolecular NMR Spectroscopy?
In Quo Vadis Biomolecular NMR Spectroscopy? Phil Selenko reviews recent methodological spin-off applications whose developments were stimulated by cellular NMR approaches.
Essay on Biomembrane Structure
Christoph Gerle provides historical outline of how we arrived at our current understanding of biomembranes and the models we use to describe them in Essay on Biomembrane Structure. A selection of direct experimental findings on the nano-scale structure of biomembranes is taken up to discuss their physical nature, and special emphasis is put on the surprising insights that arise from atomic scale descriptions.