New CIISB Newsletter just has been published
We proudly inform that Newsletter 2019 just has been published and is available on our web pages.
New microscope laboratory at the Cryo-electron microscopy core facility at CEITEC MU
The reconstruction of the Cryo-electron microscopy and tomography core facility laboratories which took place during autumn 2018 was finished in December.
PSB SYMPOSIUM "MACROMOLECULES IN ACTION"
The aim of this meeting is to illustrate how the big biological questions are resolved by combining key methods in structural biology (eg X-ray and neutron crystallography, cryo-EM, NMR and small angle scattering - SAXS and SANS)
Ten Million Euro for Access to European Proteomics Facilities
The European Union has awarded 10 million euro to a consortium of eighteen European research groups in the field of mass spectrometry-based proteomics research throughout Europe.
Instruct-ERIC Joint Research Awards: Call for proposals
Instruct is inviting applications for funding for joint research that develops new, or improves existing access services delivered by Instruct to the user community. The aim is to develop and progress technologies to a stage where they can be made available through the Instruct access programme.
Instruct Training program
We are pleased to announce that the Call for proposals for Instruct Centre Training Courses (to be held in 2019) is now open.
New cryo-TEM at CEITEC MU
New mid-range 200 kV transmission electron microscope for cryo-electron microscopy has been installed at Cryo-electron microscopy and tomography core facility CEITEC Masaryk University.
6th Open Call for Instruct-ERIC Internships
Reader's Corner Archive
The evolution of solution state NMR pulse sequences through the ‘eyes’ of triple-resonance spectroscopy
Lewis Kay in The evolution of solution state NMR pulse sequences through the ‘eyes’ of triple-resonance spectroscopy highlights how pulse sequence ‘engineering’ has evolved during past decades with the focus on liquid state NMR applications.
Visualization of biological macromolecules at near-atomic resolution: cryo-electron microscopy comes of age
The topical review by Alok K. Mitra recapitulates developments and transformational advances of cryo-EM technology.
The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryo-EM
Samar Hasnain et. al. describe the steadily-expanding methodologies for atomic resolution studies in The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryo-EM. Of note is the following statistics: Despite the wealth of structures in the Protein Data Bank, a closer examination reveals that 89% of the structures, i.e. 126 994, are of proteins or complexes with a molecular weight of less than 160 kDa. Furthermore, only 4% of the deposited structures have a molecular weight in excess of 300 kDa.