Josef Dadok National NMR Centre

The Centre is named after Professor Josef Dadok, a pioneer of nuclear magnetic resonance spectroscopy in Czechoslovakia and an important figure in the NMR instrumentation and methodology worldwide.

Core Facility of High Field NMR Spectroscopy provides access to NMR spectrometers in the range of proton frequencies from 500 MHz to 950 MHz. The equipment is suited mainly to the studies of structure, dynamics and interactions of biomolecules, i.e. proteins, nucleic acids and carbohydrates. However, the instrumentation is flexible enough to cover also various research needs in material science, organic and inorganic chemistry, biochemistry, biology and biophysics.

Key Equipment

  • NMR spectrometer for high-resolution spectroscopy in liquids (600 MHz, 700 MHz, 850 MHz and 950 MHz)
  • NMR spectrometer for high-resolution spectroscopy in liquids and solids (500 MHz and 700 MHz)

Expertise

  • High-resolution NMR of proteins, nucleic acids, and their complexes in liquids
  • Structure elucidation from NMR data at atomic resolution
  • Studies of bio-macromolecular dynamics using NMR, computational chemistry based studies of biomacromolecules

Open-access

  • Measurement of NMR spectra at magnetic fields ranging from 11.75 T to 22.32 T (corresponding to proton frequencies 500 MHz to 950 MHz)
  • Consultation of choice and setup of multidimensional experiments, data processing, and evaluation strategies
  • Measurements of complete sets of very small residual dipolar couplings (RDCs)
  • Cross-validation of RDCs in nucleic acid bases, peptide planes, and protein secondary structure elements
  • Measurement, evaluation, and interpretation of relaxation data describing intramolecular motions

Core Facility contact

Radovan Fiala - radovan.fiala@ceitec.muni.cz

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More information about Josef Dadok National NMR Centre and related services you can find in document Equipement and services of CIISB (page 17).


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