Czech Infrastructure for Integrative Structural Biology – CIISB
A gateway to realm of structural data for biochemists, biophysicists, molecular biologist, and all scientists whose research benefits from accurate structure determination of biological macromolecules, assemblies, and complex molecular machineries at atomic resolution.
Open access to 10 high-end core facilities and assisted expertise in NMR, X-ray crystallography and crystallization, cryo-electron microscopy and tomography, biophysical characterization of biomolecular interaction, nanobiotechnology, proteomics and structural mass spectrometry.
Czech national centre of European Research Infrastructure Consortium INSTRUCT ERIC.
NMR structure shows how the CTD-interacting domain of Rtt103p recognizes threonine-4 phosphorylated CTD of RNA polymerase II (RNAPII). This study suggests that the CTD code of RNAP II is degenerated as the same interaction pocket of Rtt103p can read two different phosphorylation patterns of the CTD using the same structural mechanism.
Jasnovidova, O., Krejcikova, M., Kubicek, K. & Stefl, R. Structural insight into recognition of phosphorylated threonine-4 of RNA polymerase II C-terminal domain by Rtt103p. Embo Reports 18, 906-913, doi:10.15252/embr.201643723 (2017).
High-resolution cryo-electron microscopy reconstruction of Staphylococcus aureus bacteriophage P68 from the family Podoviridae. P68 has potential to be used for phage therapy.
4. - 7.9. 2017 Dynamics of disordered proteins, workshop
Events calendar of Instruct here.
At a Royal Society awards ceremony celebrating the prestigious new European Commission-approved status for structural biology Instruct Research Infrastructure, UK Minister for Universities, Science, Research and Innovation Jo Johnson recognised the value and relevance of collaborative work between the UK and European scientists.
Instruct-ERIC decision was formally ratified by the European Commission on the 4th July 2017. An official celebration of ERIC status adoption takes place at the Royal Society, London on the 18th July 2017.
Future investments supported by the project OP VVV CIISB4HEALTH:
The project OP VVV CIISB4HEALTH (Czech Infrastructure for Integrative Structural Biology for Health) was approved by Ministry of Education Youth and Sports of the Czech Republic to cover the investment needs of the CIISB research infrastructure. The project entered into its implementation phase at the beginning of April and will last until 2019. This project brings 214 mil. CZK of the investment money to modernization and methodological development of the CIISB research infrastructure.
The 2nd iNEXT Annual Users Meeting took place on 22nd-24th May 2017, in Brno (Czech Republic). The venue was the “BEST WESTERN PREMIER Hotel International Brno”, in the very center of the second largest city of the Czech Republic, where Gregor Mendel conducted his groundbreaking experiments and established a new scientific field of genetics. Photogallery is available here.
The third Instruct Biennial Structural Biology Meeting took place in Brno, Czech Republic, from May 24 till May 26, 2017 in the International Best Western Hotel. Twodays conference showcased integrative structural biology and its impact on biological research and biomedicine.
Velké výzkumné infrastruktury - Operated by CESNET on behalf of the Council for Large Infrastructures for Research, Experimental Development and Innovation.
Instruct-ERIC - Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
iNEXT - Infrastructure for NMR, EM and X-rays for Translational Research