8 Jul 2020

Upgrade of the workflow for cryo-electron tomography and microscopy

The CIISB Cryo-electron microscopy core facility at CEITEC Masaryk University is expanding its services in the sample preparation for electron microscopy. The facility has recently acquired high-pressure freezer Leica EM ICE for vitrification of bulky biological specimen (up to 200 mm thickness). In addition, the freeze-substitution unit Leica EM AFS2 for resin embedding of the high-pressure frozen samples and the ultramicrotom Leica EM UC7 with the adapter for cryo-ultramicrotomy were purchased in order to provide the facility users with the complete workflow for preparation of thin section samples for both room-temperature electron microscopy and cryo-electron microscopy.

7 Jul 2020

Emerging Topics in Biomolecular Magnetic Resonance – Nick Cox & Kendra Frederick

The series Emerging topics in Biomolecular Magnetic Resonance will continue on July 9th at 16:00 CEST with the following lecturers and topics:

Nick Cox (Australian National University): Spin state evolution during the biological water splitting reaction

Kendra Frederick (UT Southwestern): In cell structural biology enabled by DNP MAS NMR

24 Jun 2020

Emerging Topics in Biomolecular Magnetic Resonance – 4th edition

The series Emerging topics in Biomolecular Magnetic Resonance will continue on June 25th at 16:00 CEST with the following lecturers and topics:

Melinda J. Duer (University of Cambridge): Understanding extracellular matrix disease states with solid-state NMR?

Claudio Luchinat (University of Florence): NMR for metabolomics: again the ‘second best’ technique?

16 Jun 2020

Emerging Topics in Biomolecular Magnetic Resonance – 3rd edition

The series Emerging topics in Biomolecular Magnetic Resonance will continue on June 18th at 16:00 CEST with the following lecturers and topics:

Tuo Wang (Louisiana State University): Elucidation of carbohydrate structure in plant biomass and fungal pathogens using solid-state NMR and DNP methods

Rina Rosenzweig (Weizmann Institute of Science): Molecular Chaperones in Protein Disaggregation - What we can learn from NMR

8 Jun 2020

Emerging Topics in Biomolecular Magnetic Resonance – On-line lecture series

The series will continue on Thursday, June 11, 2020 at 16:00 CEST with two cutting-edge 30 minutes presentations:

Putative Amyloids in Human Health— Insights from NMR (Ann E. McDermott, Columbia University)

An RNA dynamic ensemble at atomic resolution (Hashim Al-Hashimi, Duke University)

2 Jun 2020

New timsTOF Pro Mass Spectrometer installed at CEITEC.

New timsTOF Pro Mass Spectrometer (Bruker) has been installed at the Proteomics Core Facility, CEITEC MU. The new instrument brings another separation dimension (according collisional cross sections) in qualitative and quantitative characterization of complex protein samples as it is equipped by trapped ion mobility spectrometry (TIMS) module.

2 Jun 2020

Emerging Topics in Biomolecular Magnetic Resonance – A new on-line lecture series

A new on-line lecture series on Emerging Topics in Biomolecular Magnetic Resonance, organized by Loren Andreas, Stefan Glöggler, Christian Griesinger, Mei Hong, Oscar Millet, Art Palmer, and Markus Zweckstetter, starts on Thursday, June 4, 2020.

1 Jun 2020

Cryo-EM reaches yet another milestone – Comments on two recent cryo-EM atomic resolution studies

Two studies published during last two weeks have reported that single particle cryo-EM data can be now resolved to 1.20Å or 1.25Å, respectively. The groups of Sjors H.W. Scheres (LMB-MRC, Cambridge) and Holger Stark (MPI Göttingen) have for the first time shown that atomic resolution is attainable by single particle cryo-EM.