The project CIISB UP submitted to the OP VVV Call 02-18-046 Research Infrastructures II has been positively evaluated and will receive funding to reinvest into the existing equipment and to purchase new instrumentation in the amount 22 mil. EUR. The results were announced on October 31, 2019. Among others, new scanning transmission cryo-electron microscope with a detector for electron diffractions studies on microcrystals, fluorescence cryo-electron microscope, and new direct detectors for the existing instruments Titan Krios and Talos Arctica will be purchased. The Josef Dadok National NMR Center will benefit with upgrades of the instruments electronics and purchase of new probeheads for the high-field NMR spectrometers 500-950 MHz. Substantial acquisition of upgrades and new devices will keep up also Core Facilities for X-ray diffraction and Bio-SAXS, Crystallization of Proteins and Nucleic Acids, Biophysical Techniques, Nanobiotechnology, Proteomics and Structural Mass Spectrometry. This funding will allow CIISB to stay competitive on the European scale and will reinforce its position within the European Infrastructure consortium Instruct-ERIC as one of the leading Instruct Centers providing transnational access to its flagship technologies.