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15 Jan 2021

The 2021 ISMAR conference will be held during August 22-27

as a joint conference consisting of 22nd International Society of Magnetic Resonance Conference,  9th Asia-Pacific NMR Symposium, 60th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan
and 60th Annual Meeting of the Society of Electron Spin Science and Technology. The conference will be held as a hybrid format of on-line and virtual events with options to participate in Osaka, Japan. The on-line
format will allow participants from all the time zones to interact actively. 

12 Jan 2021

Cryo-EM data decode the mechanism behind the honeybee viral infections

How does the honeybee virus behave when infecting the host cell? Does it resemble pulling a note out of a bottle or rather opening a surprise egg? Karel Škubník and his colleagues, led by structural virologist Pavel Plevka from CEITEC Masaryk University, have discovered new findings describing the mechanism of genome release of honeybee viruses. They shed a new light on the exiting believe regarding behaviour of honeybee viruses during the host cell infection process. The scientists reached this remarkable conclusion with the help of cryo-electron microscopy combined with protein simulations, which were conducted by Robert Vácha and his research group. The research results were published on 1st January 2021 in the international scientific journal Science Advances. More details are presented in the Research Highlight below.

4 Jan 2021

New possibilities in fight against pathogenic bacteria – structure and role of protein HelD

Using cryogenic electron microscopy, three independent teams of researchers from Australia, the Czech Republic, and Germany have described the structure of a striking new complex between bacterial RNA polymerase and an accessory protein, HelD. The groups worked with a range of different components and organisms to gain a comprehensive understanding of how HelD uses a dramatic brute-force approach to prise open RNA polymerase and dislodge the tightly bound DNA and RNA.

This discovery provides an in-depth view of the bacterial transcription apparatus, and opens up pathways for development of urgently needed new antimicrobials capable of targeting serious pathogens such as the causative agent of tuberculosis. It leads to new possibilities of development of the much needed antimicrobials against serious pathogens, including the causative agent of tuberculosis. Their discoveries have been published in the Nature Communications Journal.

11 Dec 2020

New Protein Production facility at BIOCEV

The Centre of Molecular Structure at BIOCEV established a new Protein Production facility. This initiative follows the survey mapping a preliminary interest from potential users and resulted in a platform for both routine protein production and demanding development of methods in semi high-throughput format. The facility has been in a pilot mode since July 2020 to evaluate the feasibility for the long run. Now the new Protein Production facility has been added to CIISB application form and users can apply via the standard application process.

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