Upgrades of the differential scanning fluorimetry instruments Prometheus NT.48 at BIOCEV and CEITEC
Recently, both instruments Prometheus NT.48 at BIOCEV and CEITEC, permitting precise measurements of the intrinsic fluorescence of proteins, thereby characterizing their thermal unfolding, have been upgraded to include back-reflection optics, which provides insight into the aggregation processes. The basis for such detection is the aggregation-induced light scattering by particles resulting in loss of light. The combination of thermal stability detection and determination of aggregation onset temperatures allows for the most rapid, precise, and information rich analysis in formulation screenings or protein engineering projects. The upgraded instruments now can provide comprehensive results for any type of proteins, and are especially suitable for the prediction of proteins stability, for the screening of buffer influence, and for the testing of storage conditions. Part of the upgrade was also increase in the maximum possible temperature from original 95°C to 110°C . This enhancement allows to characterize proteins with higher melting temperature. Both upgrades were financed from the European Regional Development Fund-Project „CIISB4HEALTH“ (No. CZ.02.1.01/0.0/0.0/16_013/0001776).
PSB SYMPOSIUM "MACROMOLECULES IN ACTION"
The aim of this meeting is to illustrate how the big biological questions are resolved by combining key methods in structural biology (eg X-ray and neutron crystallography, cryo-EM, NMR and small angle scattering - SAXS and SANS)
Instruct-ERIC Joint Research Awards: Call for proposals
Instruct is inviting applications for funding for joint research that develops new, or improves existing access services delivered by Instruct to the user community. The aim is to develop and progress technologies to a stage where they can be made available through the Instruct access programme.
Ten Million Euro for Access to European Proteomics Facilities
The European Union has awarded 10 million euro to a consortium of eighteen European research groups in the field of mass spectrometry-based proteomics research throughout Europe.
Instruct Training program
We are pleased to announce that the Call for proposals for Instruct Centre Training Courses (to be held in 2019) is now open.