Upgrades of the differential scanning fluorimetry instruments Prometheus NT.48 at BIOCEV and CEITEC
Recently, both instruments Prometheus NT.48 at BIOCEV and CEITEC, permitting precise measurements of the intrinsic fluorescence of proteins, thereby characterizing their thermal unfolding, have been upgraded to include back-reflection optics, which provides insight into the aggregation processes. The basis for such detection is the aggregation-induced light scattering by particles resulting in loss of light. The combination of thermal stability detection and determination of aggregation onset temperatures allows for the most rapid, precise, and information rich analysis in formulation screenings or protein engineering projects. The upgraded instruments now can provide comprehensive results for any type of proteins, and are especially suitable for the prediction of proteins stability, for the screening of buffer influence, and for the testing of storage conditions. Part of the upgrade was also increase in the maximum possible temperature from original 95°C to 110°C . This enhancement allows to characterize proteins with higher melting temperature. Both upgrades were financed from the European Regional Development Fund-Project „CIISB4HEALTH“ (No. CZ.02.1.01/0.0/0.0/16_013/0001776).
ARIA Workshop and User Group meeting
Instruct-ERIC is hosting an ARIA workshop and User Group meeting on 25th February in Amsterdam.
CIISB UP project approved for financing during 2020-2022
The project CIISB UP submitted to the OP VVV Call 02-18-046 Research Infrastructures II has been positively evaluated and will receive funding to reinvest into the existing equipment and to purchase new instrumentation in the amount 22 mil. EUR.
Magnetic Resonance - An Interactive Open Access Publication of the Groupement AMPERE
The AMPERE Society has decided to launch a new publication called “Magnetic Resonance, An Interactive Open Access Publication of the Groupement AMPERE” for articles on Nuclear and Electron Magnetic Resonance and Imaging.
Advanced SAXSanalysis trainingWe would like to invite you to an Advanced SAXSanalysis training.The training is designed to help you with processing data collected with small angle X-ray scattering (SAXS) instrument in the Centre of Molecular Structure in the Institute of Biotechnology of the Czech Academy of Sciences in BIOCEV. The tutorials will be by application specialist Anton Paar (instrument manufacturer).