Upgrades of the differential scanning fluorimetry instruments Prometheus NT.48 at BIOCEV and CEITEC
Recently, both instruments Prometheus NT.48 at BIOCEV and CEITEC, permitting precise measurements of the intrinsic fluorescence of proteins, thereby characterizing their thermal unfolding, have been upgraded to include back-reflection optics, which provides insight into the aggregation processes. The basis for such detection is the aggregation-induced light scattering by particles resulting in loss of light. The combination of thermal stability detection and determination of aggregation onset temperatures allows for the most rapid, precise, and information rich analysis in formulation screenings or protein engineering projects. The upgraded instruments now can provide comprehensive results for any type of proteins, and are especially suitable for the prediction of proteins stability, for the screening of buffer influence, and for the testing of storage conditions. Part of the upgrade was also increase in the maximum possible temperature from original 95°C to 110°C . This enhancement allows to characterize proteins with higher melting temperature. Both upgrades were financed from the European Regional Development Fund-Project „CIISB4HEALTH“ (No. CZ.02.1.01/0.0/0.0/16_013/0001776).
New webpage on ciisb.org
A new page “Who is Who in Czech Structural Biology” has been added to the web site of CIISB
Save the date
Save the date – March 19-21, 2020
The XVII. Discussions in Structural Biology and 4th Users Meeting of Czech Infrastructure for Integrative Structural Biology (CIISB) jointly organized by Czech Society for Structural Biology and CIISB will take place in Nové Hrady, March 19 - March 21, 2020.
EOSC Early Adopter Programme
The second call for the EOSC Early Adopter Programme is now open!
Workshop “Upconversion Immunoassays for the Diagnosis of Bee Diseases”, September 12, 2019
CEITEC Masaryk University, Institute of Macromolecular Chemistry, Czech Academy of Science and Regensburg University organize jointly a workshop on the diagnosis of bee diseases.