On the SARS-Cov-2 Inhibitor Track
To develop specific anti-coronavirus therapeutics and prophylactics, the molecular mechanism that underlies viral infection must first be defined. The recent study published in Cell Research solved the X-ray crystal structure of six-helical bundle (6-HB) core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit, revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain, as compared to SARS-CoV. Previously developed a pan-coronavirus fusion inhibitor, EK1, which targeted the HR1 domain, was used as a starting molecule to design a series of new inhibitors, of which EK1C4 potently inhibited the replication of 5 live human coronaviruses examined, including SARS-CoV-2. Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection, suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs.
CMS BIOCEV Newsletter
Heads of BIOCEV CIISB core facilities have summarised recent technological upgrades of their laboratories and presented them as CMS newsletter. The overview of recent updates is available here.
Research scientist for the Centre of Molecular Structure - Biophysical methods facility
Biophysical Methods facility of BIOCEV is looking for a research scientist specialised in biophysical techniques and/or spectroscopic techniques.
Instruct-ERIC is hiring a Director to join the Instruct Hub
The Integrated Structural Biology - European Research Infrastructure Consortium (Instruct-ERIC), a pan-European distributed infrastructure whose principal task is to support excellent science that integrates an understanding of biological structure with cellular function, seeks to recruit a director.
Two on-line Magnetic Resonance Courses
Ilja Kuprov and Marcel Utz from University of Southampton made entire Undergraduate Magnetic Resonance module available online: 20 hours of video and 100+ pages of handouts.