How SARS-CoV-2 binds to human cells
Scientists are racing to learn the secrets of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemic disease COVID-19. On Friday, March 27 , 2020 Yuanyuan Zhan et al. from Westlake Institute of Advanced Study, Hangzhou, China, published in Science a study entitled Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. The first step in viral entry is the binding of the viral trimeric spike protein to the human receptor angiotensin-converting enzyme 2 (ACE2). Authors present the structure of human ACE2 in complex with a membrane protein that it chaperones, B0AT1. In the context of this complex, ACE2 is a dimer. A further structure shows how the receptor binding domain of SARS-CoV-2 interacts with ACE2 and suggests that it is possible that two trimeric spike proteins bind to an ACE2 dimer. The structures provide a basis for the development of therapeutics targeting this crucial interaction. Data were obtained using cryo-electron microscopy and details are presented with an overall resolution of 2.9 angstroms, with a local resolution of 3.5 angstroms at the ACE2-RBD interface.
Postdoc positions at CEITEC – Cryo-ET and Cryo-EM of Viral Transcription-Translation Coupling
Two postdoc positions are available in newly established Gabriel Demo lab (CEITEC, Masaryk University, Brno, Czech Republic) to participate in research focused on structural mechanisms of transcription-translation coupling in bacteria and potentially in virus-infected mammalian cells.
New CIISB newsletter has been published
Newsletter summarising new developments at CIISB in the period February - July 2020 and planned events is now available.
CMS BIOCEV Newsletter
Heads of BIOCEV CIISB core facilities have summarised recent technological upgrades of their laboratories and presented them as CMS newsletter. The overview of recent updates is available here.
Research scientist for the Centre of Molecular Structure - Biophysical methods facility
Biophysical Methods facility of BIOCEV is looking for a research scientist specialised in biophysical techniques and/or spectroscopic techniques.