Biomacromolecular Crystallization Workshop

In this workshop, the attendees should gain the knowledge about various aspects of crystallization as well as about the whole process of structure determination.

Crystallization of biomacromolecules (proteins, nucleic acids) and their complexes is a well-established method in 3D structure determination. Since 1970's it resulted in almost 120 000 individual structures (90% of all structures in PDB). Obtaining the crystal is a crucial step of the technique, since macromolecular crystallization is a macromolecule concentration, composition of precipitant solution, technique applied, size/volume of the mixed drop, temperature, impurities, handling, etc.

In this workshop, the attendees should gain the knowledge about various aspects of crystallization as well as about the whole process of structure determination. Practical part (limited to 12 persons) will be focused on real crystallization set-up by several techniques including high-thoughput automation.