Structural Mass Spectrometry CF at BIOCEV acquired a new MALDI-TOF mass spectrometer
The structural mass spectrometry core facility at BIOCEV has expanded its equipment offer (and associated services) with several items.
The core facility now provides access to a new MALDI-TOF mass spectrometer, an Autoflex Speed device from Bruker Corporation. This instrument is suited mostly for the routine detection of peptides and intact proteins. The availability of this new device increases the throughput of analyzed samples, which was previously limited by the lengthy reservation times for accessing the 15T SolariX FT-ICR instrument.
Further, the new excimer laser for fast photo oxidative labeling of proteins will be used for monitoring of fast structural changes of proteins or protein-protein and protein-DNA complexes. A new UHLPC system will be installed in few days to increase the performance of analytes separation. The acquisition of new components was financed from European Regional Development Fund-Project „CIISB4HEALTH“ (No. CZ.02.1.01/0.0/0.0/16_013/0001776).
Nadrian C. Seeman: DNA, not Merely the Secret of Life
We build branched DNA species that can be joined using Watson-Crick base pairing to produce N-connected objects and lattices. We have used ligation to construct DNA topological targets, such as knots, polyhedral catenanes, Borromean rings and a Solomon's knot.
An Instruct/CIISB course took place at the CMS, IBT, Biocev on April 5 and 6, 2018.
This course/workshop allowed participants, with some prior knowledge and experience in macromolecular crystallography, to access the biophysical measurements section and the crystal handling/X-ray diffraction section of the Instruct CZ / CIISB CMS core facility for three practical work sessions.
XV. Discussions in Structural Molecular Biology and the 2nd User Meeting of the Czech Infrastructure for Integrative Structural Biology
In March, 2018, the Czech and Slovak community of structural biologists met at the "XV. Discussions in Structural Molecular Biology".
1st CEITEC Symposium on Recent Advances in Cryo-Electron Microscopy
Cryo-electron Microscopy and Tomography CEITEC Masaryk University has organized a one day symposium on recent developments in the field of cryo-electron microscopy on 18thApril 2018.