2017 Nobel Prize in Chemistry - Cryo-electron Microscopy
The Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution".
In 1990, Richard Henderson succeeded in using an electron microscope to generate a three-dimensional image of a protein at atomic resolution. This breakthrough proved the technology’s potential. Joachim Frank made the technology generally applicable. Between 1975 and 1986 he developed an image processing method in which the electron microscope’s fuzzy two-dimensional images are analysed and merged to reveal a sharp three-dimensional structure. Jacques Dubochet added water to electron microscopy. Liquid water evaporates in the electron microscope’s vacuum, which makes the biomolecules collapse. In the early 1980s, Dubochet succeeded in vitrifying water – he cooled water so rapidly that it solidified in its liquid form around a biological sample, allowing the biomolecules to retain their natural shape even in a vacuum. For more details look here: https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2017/
New state-of-the-art SAXSpoint 2.0 instrument installed at the Centre of Molecular Structure
The Peter Sedmer Award for 2018 was presented
Annually presented price for outstanding work published in the area of nuclear magnetic resonance in memory of Petr Sedmera, a renowned scientist who greatly contributed to the development of the field.
New Orbitrap Fusion Lumos Tribrid Mass Spectrometer installed at CEITEC
The new instrument equipped at the Proteomics Core Facility, CEITEC MU.
Nadrian C. Seeman: DNA, not Merely the Secret of Life
We build branched DNA species that can be joined using Watson-Crick base pairing to produce N-connected objects and lattices. We have used ligation to construct DNA topological targets, such as knots, polyhedral catenanes, Borromean rings and a Solomon's knot.